The AIR contains detailed information on the molecular pathways involved in the regulation of biological processes (= phenotypes). Because those pathways are directed, i.e. contain information on the type of regulation, positive or negative, we assume that we can predict changes in the phenotype activity based on the influence of their regulating elements and context-specific omics data mapped on the AIR. For instance, if positive regulators of a specific phenotype show an increase in their expression, i.e. have a positive logFC value, we assume that the activity of this particular phenotype has increased as well and vice versa. The following figure explains the algorithm used for the calculations:
The „PhenotypePrediction“ plugin of the AIR integrates this algorithm and enables users to upload their own data files, visualize the results directly on the AIR or download them for their own analyses.