I am a data scientist, using mathematics and computational tools to make sense of data. My work focusses on understanding how the functioning of cellular systems emerges from the interactions between the system’s parts, and how these emergent properties of a system as a whole enable or constrain the behaviour of its parts. Despite technological advances, that allow us to identify and characterise cellular components, the principles by which cells and tissues realise their function, remain poorly understood. My approach combines data-driven modelling with model-driven experimentation, using a wide range of computational and mathematical tools, including machine learning, statistics, systems theory, stochastic processes and category theory. The results of my work support basic biological and medical research.
|2017– to date||Adjunct Professor, Chhattisgarh Swami Vivekanand Technical University, India|
|2005||Fellow of the Stellenbosch Institute for Advanced Study (STIAS), Stellenbosch, South Africa|
|2004 – to date||Adjunct Professor, Dept. of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio, USA|
|2003 – to date||Full Professor (C4/W3), Dept. of Systems Biology & Bioinformatics, Faculty of Computer Science and Electrical Engineering, University of Rostock, Germany|
|2003 – 2006||Visiting Reader, School of Mathematics, The University of Manchester, UK|
|2002 – 2003||Senior Lecturer. Joint appointment between the Dept. of Biomolecular Sciences and the Dept. of Electrical Engineering, University of Manchester Institute of Science and Technology (UMIST), UK|
|1999 – 2000||Senior Research Fellow (by invitation), Faculty of Information Technology and Systems, Delft University of Technology, Netherlands|
|1997 – 2000||
Lecturer, Lucas Varity Research Lectureship, Control Systems Centre, UMIST, Manchester, UK
|1997||Ph.D. Dissertation title: Possibility Theory with Applications to Data Analysis. Control Systems Centre, University of Manchester Institute of Science and Technology (UMIST), UK|
|1994 – 1997||Research Associate, Control Systems Centre, UMIST, Manchester, UK|
|1993||Research Assistant, Institute of Biomedical Engineering, Medical Academy Carl Gustav Carus, Dresden, Germany|
|1993 – 1994||B.Eng. (hons) 1st School of Systems Engineering, University of Portsmouth, UK|
|1991 – 1993||Teacher, Stiftung für Berufliche Bildung, Hamburg|
|1989 – 1993||Dipl.Ing. (FH) Control Engineering, Dept of Electrical Engineering and Computer Science. University of Applied Sciences, Hamburg, Germany|
|1985 – 1988||Industrial apprentice, completed with distinction. AEG Systems Technology, Hamburg|
My work involves various advisory functions to ministries, funding bodies, award committees and consultancy for companies. Over the years, I have coordinated several research consortia in the UK, Germany and for the European Commission. I am the member of scientific advisory boards for several systems biology institutes and initiatives across Europe.
I am the founding editor of the first international journal in Systems Biology. I have written four books, including the research monograph “Possibility Theory with Applications to Data Analysis” (Wiley), the textbooks “Data Engineering” (Wiley) and “Stochastic Approaches for Systems Biology” (Springer). Another, more unusual book is an introductory conversation handbook for 'Plattdeutsch' (lower German) an old language that is spoken by only few people. I have edited other books, including a volume on “Systems Biology” (Portland Press), the Encyclopaedia of Systems Biology (Springer), a book on MicroRNA Cancer Regulation (Springer) and in 2016 a book on Systems Medicine (Springer). I am also the editor of the upcoming Encyclopaedia of Systems Medicine.
Awards and Distinctions
|2016– 2019||Elected member of the DFG review panel Foundations of Medicine and Biology, German Research Foundation (DFG)|
|2009||SPIE Pioneer Award|
|1994||IBM Computing Prize for best Final Year Project|
My teaching focusses on data analysis and mathematical modelling with applications in the life sciences, i.e., Bioinformatics, Systems Biology, Systems Medicine. We have more than 15 years of experience in teaching interdisciplinary courses at graduate level. Our students are coming from biology, medicine, physics, mathematics, engineering and computer science. Over the years, I have also enjoyed the organisation and teaching at various international summer and winter schools.
I am also offering a one day course on Science Communication through which I share my experience as an academic. The course has been booked by various universities and institutes as part of their doctoral and postdoctoral training programmes.
Scientific data do not speak for themselves but require an argument to be accepted as facts. For facts to be trusted and results being accepted, we must communicate them effectively. Therefore, scientists are, to some extent, only as clever as others think they are. The communication of scientific results is therefore at least as important as their generation but most university degrees and PhD programmes provide no or very limited training in science communication.
In this course, we learn a strategy to effectively communicate research in paper abstracts, in grant applications, through websites as well as in oral and poster presentations. Our analysis reveals strategies to structure and formulate texts. These findings contribute to a more successful communication of the participant’s work and identify strategies for effective forms of writing. The concept is not specific to a particular field and is well suited for researchers and students in the engineering, biomedical, biological, medical and physical sciences.
Other Interests and Activities
- "Auf der Suche nach Regeln und Ausnahmen" an essay about the interaction of cells within a larger group of cells was published in the Laborjournal (in German)
- Interview for systembiologie.de (pdf)
- Interview for the Systems Medicine Web Hub (pdf)
- Interview for the BMBF (in German) (pdf)
- An autobiographical article describing my path from engineering to biomedicine (IET Systems Biology, 2014)
- An essay (in German) on my origins in northern Germany and a book (published with Quickborn, Hamburg) I have written in "Plattdeutsch" - a language of northern Germany, spoken by a tiny minority along the coasts of the north and baltic seas. See also this newspaper article for a description 'op platt' (Kieler Nachrichten, 16. November 2012).
- Some "philosophical" musings on systems theory and systems biology can be found in an interview with The Reasoner, Vol. 5, Nr. 9, September 2011.
- A science policy briefing on Systems Biology for Medical Applications that I prepared for the European Science Foundation (see also Advancing systems biology for medical applications).
- In remembrance of Allan Muir.
- Collection of some of my favorite quotations, aphorisms and thoughts that have motivated and influenced my thinking.
- A review (pdf) of D. Ellerman: Adjoints and emergence: applications of a new theory of adjoint functors. Axiomathes (2007) 17:19-39.
- The Beauty of Mathematics - A Rough Sketch for a Proof (pdf), essay.
- Selbstorganisation: Eine charakterische Eigenschaft lebender Systeme (November 2007): Video, 8 min, 7 mb (wma) oder Pdf-Datei (pdf).
- An article in the Kiteboarding magazine, with my thoughts about surfing and music, describing why and how one can find happiness by living the moment (In German).
As part of my training as an Elektronaut I prepared some How to guides, Cheat sheets and notes that may be of help to other Elektron musicians:
- Elektron Music Production Tips
- Graphical representation of Octatrack Concepts
- Graphical representation of the Analog Four Structure
- Graphical representation of the Analog Rytm Sound Architecture
- Graphical representation of Analog Rytm Concepts
- Sheets for note taking with the Analog Rytm
I don't play chess but I am interested in the question of how complexity emerges from simplicity. Here are some notes I prepared while reading chess books and which may be useful for a novice: